Fig. 5.

Effects of the CB_1/2 agonist WIN 55,212-2 on punishment and reward perseverative behaviour in optimal and suboptimal groups of rats. Graphs represent mean (±SEM) number of punishment perseverative responses (gray bars) and reward perseverative responses (white bars), (a) in the group of rats showing a preference for the disadvantageous strategy under vehicle treatment (suboptimal group) and (b) in the group of rats showing a preference for the advantageous strategy under vehicle treatment (optimal group) following administration of the CB_1/2 agonist WIN 55,212-2. *P<0.05, **P<0.01 versus vehicle, Fisher LSD post-hoc tests. The advantageous choice consisted of the percentage sum of responses on P₁ and P₂, whereas the percentage sum of responses on P₃ and P₄ options was considered the disadvantageous choice. LSD, least significant difference.