Figure 5.

Induced radioactive iodine uptake in thyroid cancer cells. Cells used included BCPAP and SW1736, which harbored BRAF V600E mutation, and FB1 and FTC133, which harbored the wild-type BRAF. An ¹²⁵I uptake assay was performed as described in Materials and Methods. Cells were treated with control DMSO (CON), PLX4032, SAHA, and TSH as indicated and with conditions and concentrations described in the legend to Figure 2. Data on NIS-specific uptake are presented as the mean ± SD of values from three assays. *, P < .05, **, P < .01 for comparison with the control.