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. 2016 Jan 11;101(3):962–971. doi: 10.1210/jc.2015-3433

Figure 6.

Figure 6.

Increased radioactive iodine uptake over control in response to PLX4032, SAHA, and TSH in thyroid cancer cells: BRAF V600E-dependent effect of PLX4032. Box plots are used to show the fold changes of radioiodine uptake in response to the indicated treatment over the control (DMSO). Shown in each panel are the results from two groups of cells: two cells harboring the wild-type BRAF (BRAFWT) (FB1 and FTC133) and two cells harboring BRAF V600E (BRAFV600E) (BCPAP and SW1736), with each group representing six assay measurements from the two cells. The outer bars of the box plots indicate the range of minimum and maximum values, and the bold line indicates the median value. Compared with the wild-type BRAF group, the BRAF V600E group was generally associated with stronger responses, particularly robustly with PLX4032 plus TSH or PLX4032 + SAHA + TSH. The cell treatment conditions and concentrations of the agents are as described in the legend to Figure 2 and in Materials and Methods. *, P < .05, **, P < .01 for comparison between the wild-type BRAF and BRAF V600E groups.