Table 2.
Gene Expression Data in the Abdominal Subcutaneous Fat Among Non-HIV-Infected Subjects and HIV-Infected Subjects (n = 27)
| Non-HIV-Infected (n = 9) | HIV-Infected (n = 18) | P Value, Non-HIV vs HIV | Non-HIV-Infected (n = 9) | HIV-Infected Nonlipodystrophic (n = 9) | HIV-Infected Lipodystrophic (n = 9) | Overall P Valuea | P Value, Non-HIV vs Nonlipodystrophic HIV | P Value, Non-HIV vs HIV Lipodystrophic | P Value, HIV Nonlipodystrophic vs HIV Lipodystrophic | |
|---|---|---|---|---|---|---|---|---|---|---|
| Dicer | 17.69 (10.72, 47.91) | 4.88 (1.91, 11.93) | .01 | 17.69 (10.72, 47.91) | 11.20 (4.83, 21.45) | 2.49 (0.02, 4.88) | .002 | .22 | .003 | .006 |
| Brown adipose tissue markers | ||||||||||
| UCP1 | 0.17 (0.08, 0.28) | 0.14 (0.01, 0.29) | .52 | 0.17 (0.08, 0.28) | 0.16 (0.07, 1.45) | 0.01 (0.00, 0.20) | .16 | N/A | N/A | N/A |
| PGC1α | 31.12 (7.14, 56.02) | 0.24 (0.02, 11.88) | .004 | 31.12 (7.14, 56.02) | 11.71 (0.56, 33.12) | 0.03 (0.00, 0.14) | .0003 | .16 | .0006 | .002 |
| ZIC1 | 64.45 (39.43, 185.94) | 6.48 (0.53, 42.63) | .007 | 64.45 (39.43, 185.94) | 37.14 (15.14, 138.59) | 1.02 (0.06, 2.78) | .0005 | .25 | .0006 | .004 |
| LHX8 | 0.23 (0.08, 0.47) | 0.11 (0.01, 0.17) | .06 | 0.23 (0.08, 0.47) | 0.13 (0.06, 0.38) | 0.01 (0.00, 0.13) | .01 | .54 | .009 | .03 |
| PRDM16 | 1.57 (0.23, 2.27) | 0.20 (0.02, 0.56) | .03 | 1.57 (0.23, 2.27) | 0.51 (0.30, 1.45) | 0.02 (0.00, 0.16) | .0007 | .54 | .002 | .0008 |
| PAT2 | 0.31 (0.18, 0.49) | 0.28 (0.04, 0.49) | .33 | 0.31 (0.18, 0.49) | 0.39 (0.28, 0.94) | 0.04 (0.00, 0.27) | .01 | .54 | .02 | .008 |
| P2RX5 | 0.35 (0.17, 1.15) | 0.33 (0.11, 2.18) | .80 | 0.35 (0.17, 1.15) | 1.99 (0.20, 4.50) | 0.14 (0.00, 0.51) | .04 | .29 | .12 | .02 |
| Beige adipose tissue markers | ||||||||||
| TMEM26 | 0.78 (0.50, 1.33) | 0.79 (0.20, 2.59) | 1.00 | 0.78 (0.50, 1.33) | 2.54 (0.79, 3.68) | 0.24 (0.01, 0.75) | .005 | .06 | .07 | .004 |
| CD137 | 5.17 (2.53, 8.61) | 2.00 (0.15, 5.71) | .11 | 5.17 (2.53, 8.61) | 4.11 (2.13, 37.84) | 0.17 (0.01, 2.00) | .006 | 1.00 | .006 | .008 |
| Other metabolic markers | ||||||||||
| DIO2 | 75.06 (33.38, 120.85) | 9.54 (0.22, 54.54) | .03 | 75.06 (33.38, 120.85) | 53.63 (12.36, 153.74) | 0.26 (0.03, 3.53) | .0007 | .60 | .001 | .002 |
| Leptin | 77.98 (20.18, 112.04) | 3.55 (0.12, 87.90) | .08 | 77.98 (20.18, 112.04) | 68.36 (13.16, 296.16) | 0.12 (0.01, 3.55) | .001 | .86 | .001 | .003 |
| HSP60 | 325.16 (219.2, 643.9) | 48.33 (1.75, 179.90) | .004 | 325.16 (219.2, 643.9) | 164.28 (79.79, 851.49) | 2.09 (0.22, 4.59) | .0001 | .19 | .0004 | .0004 |
Abbreviation: N/A, not applicable. Nonnormally distributed data are reported as median (interquartile range). Gene expression values are normalized to TBP, and results are expressed as ratios in arbitrary units.
a
Overall P value was obtained by a Kruskal-Wallis test.