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. 2015 Dec 16;101(3):1091–1097. doi: 10.1210/jc.2015-3279

Figure 1.

Figure 1.

Somavaratan pharmacokinetic parameters. A, Plasma somavaratan concentrations (ng/mL) after a single sc dose administration (phase 1b). Data shown for 3 days after dose includes patients with samples taken 2 and 4 days after dose. The molecular weight of somavaratan is 119 kDa, with rhGH contributing 22 kDa and the remaining mass contributed by the XTEN construct. B, Linear correlation of log-transformed somavaratan pharmacokinetic parameters (Cmax, AUC) to log-transformed phase 1b somavaratan doses. Cmax and AUC were estimated using a single compartmental model.