Table 3.
HRpQCT Parameters by Vitamin D Status at the Radius and Tibia
| 25OHD <20 ng/ml | 25OHD 20–29 ng/ml | 25OHD ≥30 ng/ml | P Value | P Value Adjusted for Age and Weight | P Value Adjusted for Age, Weight, and Sex | |
|---|---|---|---|---|---|---|
| Radius | ||||||
| Total area (mm2) | 259 ± 16 | 286 ± 12 | 255 ± 10 | .12 | .24 | .21 |
| Total vBMD (mg HA/cm3) | 282 ± 17 | 277 ± 12 | 267 ± 11 | .72 | .63 | .65 |
| Cortical vBMD (mg HA/cm3) | 842 ± 22 | 806 ± 16 | 812 ± 14 | .38 | .12 | .17 |
| Direct cortical thickness (mm) | 0.944 ± 0.052 | 0.876 ± 0.039 | 0.872 ± 0.032 | .48 | .41 | .56 |
| Cortical porosity (%) | 2.1 ± 0.3 | 2.3 ± 0.2 | 2.5 ± 0.2 | .43 | .96 | .99 |
| Trabecular vBMD (mg HA/cm3) | 118 ± 10 | 135 ± 7 | 121 ± 6 | .25 | .21 | .26 |
| Dinn (mg HA/cm3) | 74 ± 10 | 98 ± 7 | 83 ± 6 | .11 | .08 | .11 |
| Dmeta (mg HA/cm3) | 182 ± 10 | 192 ± 7 | 181 ± 6 | .44 | .39 | .44 |
| Tb.N (1/mm) | 1.65 ± 0.10 | 1.86 ± 0.07 | 1.76 ± 0.06 | .20 | .06 | .07 |
| Tb.Th (mm) | 0.058 ± 0.003 | 0.059 ± 0.002 | 0.056 ± 0.002 | .46 | .95 | .99 |
| Tb.Sp (mm) | 0.575 ± 0.049 | 0.517 ± 0.035 | 0.561 ± 0.031 | .55 | .36 | .39 |
| Tb.Sp sd (mm) | 0.300 ± 0.054 | 0.257 ± 0.039 | 0.311 ± 0.034 | .57 | .58 | .61 |
| Whole bone stiffness (kN/mm) | 33.5 ± 2.7 | 33.9 ± 2.0 | 29.5 ± 1.7 | .19 | .54 | .50 |
| Failure load (kN) | 1.6 ± 1.3 | 1.6 ± 0.9 | 1.4 ± 0.8 | .16 | .50 | .47 |
| Tibia | ||||||
| Total area (mm2) | 765 ± 34 | 764 ± 25 | 714 ± 21 | .22 | .82 | .98 |
| Total vBMD (mg HA/cm3) | 271 ± 16 | 252 ± 11 | 231 ± 10 | .08 | .53 | .50 |
| Cortical vBMD (mg HA/cm3) | 782 ± 21 | 774 ± 15 | 759 ± 13 | .59 | .20 | .22 |
| Direct cortical thickness (mm) | 1.24 ± 0.06 | 1.23 ± 0.04 | 1.11 ± 0.04 | .053 | .92 | .65 |
| Cortical porosity (%) | 6.8 ± 0.6 | 7.1 ± 0.5 | 7.1 ± 0.4 | .92 | .18 | .19 |
| Trabecular vBMD (mg HA/cm3) | 141 ± 9 | 153 ± 6 | 140 ± 5 | .25 | .37 | .49 |
| Dinn (mg HA/cm3) | 95 ± 10 | 107 ± 7 | 95 ± 6 | .39 | .47 | .57 |
| Dmeta (mg HA/cm3) | 208 ± 8 | 222 ± 6 | 209 ± 5 | .20 | .25 | .37 |
| Tb.N (1/mm) | 1.86 ± 0.10 | 1.83 ± 0.07 | 1.78 ± 0.06 | .77 | .70 | .61 |
| Tb.Th (mm) | 0.065 ± 0.003 | 0.070 ± 0.002 | 0.066 ± 0.002 | .25 | .19 | .23 |
| Tb.Sp (mm) | 0.518 ± 0.038 | 0.503 ± 0.03 | 0.528 ± 0.024 | .80 | .65 | .67 |
| Tb.Sp sd (mm) | 0.285 ± 0.052 | 0.255 ± 0.037 | 0.288 ± 0.032 | .79 | .67 | .69 |
| Whole bone stiffness (kN/mm) | 105.4 ± 6.3 | 109.9 ± 4.7 | 93.0 ± 3.8a | .02 | .40 | .45 |
| Failure load (kN) | 4.9 ± 2.9 | 5.1 ± 2.1 | 4.4 ± 1.8a | .02 | .49 | .55 |
Abbreviations: Dinn, inner trabecular vBMD; Dmeta, outer trabecular vBMD; Tb.Sp, trabecular separation.
a
P < 0.05 vs 25OHD 20–29; values represent group mean ± sem.