Table 3.

Statistical Analysis of PD End Points (IGF-1 and IGFBP-3) After Multiple Doses of NNC0195-0092 Compared With Daily Norditropin NordiFlex

Dose Level, mg/kga	Estimated Mean Ratio AUC0–168h	95% CI	P Value	Estimated Mean Ratio Cmax	95% CI	P Value
IGF-1
0.02 mg/kg/Norditropin NordiFlex	0.87	[0.66, 1.13]	.2713	0.95	[0.72, 1.24]	.6896
0.04 mg/kg/Norditropin NordiFlex	1.08	[0.82, 1.43]	.5719	1.13	[0.85, 1.50]	.3940
0.08 mg/kg/Norditropin NordiFlex	1.37	[1.04, 1.82]	.0275	1.48	[1.12, 1.97]	.0086
0.12 mg/kg/Norditropin NordiFlex	2.32	[1.77, 3.04]	<.0001	2.52	[1.92, 3.32]	<.0001
IGFBP-3
0.02 mg/kg/Norditropin NordiFlex	0.92	[0.84, 1.01]	.0929	0.98	[0.88, 1.09]	.6646
0.04 mg/kg/Norditropin NordiFlex	1.01	[0.91, 1.12]	.8380	1.03	[0.92, 1.15]	.5697
0.08 mg/kg/Norditropin NordiFlex	1.02	[0.93, 1.13]	.6460	1.04	[0.93, 1.16]	.5043
0.12 mg/kg/Norditropin NordiFlex	1.19	[1.08, 1.31]	.0010	1.19	[1.06, 1.32]	.0031

Abbreviation: CI, confidence interval.

^aAssessments at dose 4 for NNC0195-0092 and at week 4/day 22 for Norditropin NordiFlex.