Table 3. The diagnostic abilities of each liver fibrosis marker for assessing the stage of liver fibrosis.
| Fibrosis stage | Optimal cutoff | AUROC | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
|---|---|---|---|---|---|---|---|
| Fuc-Hpt, U/mL | F ≥ 2 | 654 | 0.67702 | 59.0 | 72.4 | 68.8 | 63.1 |
| F ≥ 3 | 730 | 0.73835 | 73.0 | 70.0 | 42.5 | 89.5 | |
| F4 | 966 | 0.81333 | 81.3 | 73.1 | 13.8 | 98.7 | |
| Mac-2 bp, ng/mL | F ≥ 2 | 1595 | 0.74741 | 75.2 | 64.1 | 68.4 | 71.4 |
| F ≥ 3 | 2352 | 0.73393 | 64.9 | 72.4 | 41.7 | 87.1 | |
| F4 | 3029 | 0.79651 | 75.0 | 77.7 | 15.2 | 98.3 | |
| Platelet count, ×104/μL | F ≥ 2 | 15.0 | 0.72135 | 59.0 | 74.4 | 70.4 | 63.7 |
| F ≥ 3 | 12.8 | 0.78893 | 66.2 | 79.4 | 49.5 | 88.5 | |
| F4 | 9.4 | 0.85237 | 62.5 | 92.0 | 29.4 | 97.9 | |
| Hyaluronic acid *, ng/mL | F ≥ 2 | 75.6 | 0.77091 | 65.3 | 77.3 | 75.0 | 68.1 |
| F ≥ 3 | 85.0 | 0.80925 | 78.6 | 69.5 | 42.7 | 91.5 | |
| F4 | 155.8 | 0.84591 | 78.6 | 78.2 | 18.0 | 98.4 | |
| APRI | F ≥ 2 | 0.65 | 0.76411 | 82.0 | 60.3 | 68.0 | 76.4 |
| F ≥ 3 | 0.86 | 0.78192 | 85.1 | 62.5 | 40.9 | 93.3 | |
| F4 | 1.11 | 0.82828 | 87.5 | 66.4 | 12.2 | 99.0 | |
| FIB4 index | F ≥ 2 | 2.71 | 0.76867 | 63.4 | 79.5 | 76.1 | 67.8 |
| F ≥ 3 | 3.31 | 0.82710 | 70.3 | 82.3 | 54.7 | 90.1 | |
| F4 | 5.83 | 0.87645 | 62.5 | 94.0 | 32.3 | 97.9 |
*The hyaluronic acid analysis was performed in 243 cases as a reference because 74 values were missing values. PPV: Positive predictive value. NPV: Negative predictive value.