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. 2016 Mar 22;11(3):e0151233. doi: 10.1371/journal.pone.0151233

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© 2016 Meunier et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — D-serine modulates synaptic NMDARs current at VC L5PyNs A: Immunofluorescence for D-serine, and GFAP revealed that D-serine is expressed across all layers of P22-25 (5 slices, 3 animals) VC. The D-serine producing enzyme serine racemase (SR) was also found to be expressed and co-localized with the astroglial marker GFAP. Images are Z-stack of 10 serial confocal images with a thickness of 1μm. Scale bars: left, 200 μm; right, 50μm B-D: Applications of the D-serine degrading enzyme RgDAAO (0.2 U/ml) reduces synaptically evoked NMDA-EPSCs (n = 5 cells, 5 slices, 2 animals) (B) while its inactive form ΔRgDAAO has no effect (n = 5 cells, 5 slices, 2 animals) (D). Scale bars: 100pA, 500ms. Conversely D-serine (100 μM) significantly potentiates NMDA-EPSCs (n = 5 cells, 5 slices, 2 animals) (C) Scale bars: 200pA, 500ms. ***p<0.001.