Table 2. Neurology analysis by modified SHIRPA of line Pou3f3L423P.
| Males | Females | Genotype: P-value | |||
|---|---|---|---|---|---|
| Parameter | Homozygous mutant | Wild-type | Homozygous mutant | Wild-type | |
| Body weight (g) | 22.4 ± 1.7 | 27.7 ± 2.2 | 18.9 ± 1.8 | 24.9 ± 2.8 | c |
| Locomotor activity (floor squares crossed) | 11.1 ± 10.2 | 7.4 ± 5.8 | 10.8 ± 7.9 | 16.4 ± 7.1 | |
| Lacrimation | 5 of 14 | 0 of 16 | 6 of 12 | 0 of 16 | c |
| Pelvic elevation (more than 5) | 4 of 14 | 0 of 16 | 3 of 12 | 0 of 16 | b |
| Tail elevation: horizontal extension | 4 of 14 | 0 of 16 | 5 of 12 | 4 of 16 | 0.06 |
| Trunk curl: present | 8 of 14 | 3 of 16 | 9 of 12 | 4 of 16 | b |
| Urination: absent | 12 of 14 | 7 of 16 | 6 of 12 | 7 of 16 | 0.07 |
| Contact righting reflex: absent | 11 of 14 | 2 of 16 | 8 of 12 | 1 of 16 | c |
8-week-old mice were tested. No. per genotype and sex: n = 12–16. Data are presented as mean ± standard deviation (body weight, locomotor activity) and as exact numbers. Significance vs. wild-type controls: b, P < 0.01; c, P < 0.001.