Table 4. Clinical chemical analysis of line Pou3f3L423P.
| Males | Females | Genotype: P-value | |||
|---|---|---|---|---|---|
| Parameter | Homozygous mutant | Wild-type | Homozygous mutant | Wild-type | |
| Na+ (mmol/l) | 153 ± 1 | 153 ± 1 | 151 ± 3 | 150 ± 4 | |
| K+ (mmol/l) | 5.1 ± 0.4 | 4.6 ± 0.3 | 4.7 ± 0.3 | 3.9 ± 0.3 | c |
| Ca2+ (mmol/l) | 2.4 ± 0.1 | 2.5 ± 0.1 | 2.5 ± 0.1 | 2.4 ± 0.1 | |
| Cl- (mmol/l) | 109 ± 1 | 108 ± 2 | 112 ± 3 | 110 ± 3 | b |
| Fe (μmol/l) | 38.0 ± 3.4 | 36.8 ± 3.8 | 40.5 ± 8.8 | 37.6 ± 3.8 | |
| Pi (mmol/l) | 1.5 ± 0.3 | 1.5 ± 0.2 | 1.7 ± 0.3 | 2 ± 0.4 | |
| Total protein (g/l) | 53.2 ± 1.4 | 56.1 ± 1.8 | 52.7 ± 1.3 | 53.5 ± 2.4 | c |
| Albumin (g/l) | 29.7 ± 3.4 | 31.5 ± 1 | 30.5 ± 2.5 | 32 ± 1.6 | b |
| Creatinine (μmol/l) | 16.5 ± 1.3 | 15.9 ± 1.0 | 16.5 ± 2.8 | 11.1 ± 2.4 | c |
| Urea (mmol/l) | 20.8 ± 1.8 | 10.7 ± 0.9 | 18.7 ± 2.1 | 8.7 ± 1.3 | c |
| Cholesterol (mmol/l) | 3.5 ± 0.2 | 4.3 ± 0.4 | 3.1 ± 0.2 | 3.3 ± 0.4 | c |
| Triglycerides (mmol/l) | 2.2 ± 0.6 | 3.4 ± 0.8 | 2.1 ± 0.6 | 3.0 ± 1.0 | c |
| ALT (U/l) | 45 ± 50 | 33 ± 7 | 27 ± 5 | 28 ± 6 | |
| AST (U/l) | 72 ± 30 | 51 ± 8 | 72 ± 22 | 48 ± 7 | c |
| AP (U/l) | 132 ± 14 | 111 ± 9 | 148 ± 25 | 132 ± 14 | c |
| α-Amylase (U/l) | 717 ± 86 | 726 ± 55 | 694 ± 59 | 623 ± 59 | |
| Glucose (mmol/l) | 9.4 ± 1.8 | 10.6 ± 2.2 | 10.4 ± 2.0 | 11.5 ± 1.8 | a |
| LDH (U/l) | 250 ± 104 | 178 ± 38 | 239 ± 53 | 181 ± 39 | c |
Creatinine, plasma creatinine analyzed by the enzymatic method; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AP, alkaline phosphatase; LDH, lactate dehydrogenase.
15-week-old mice were tested. No. per genotype and sex: n = 13–16. Data are presented as mean ± standard deviation. Significance vs. wild-type controls: a, P < 0.05; b, P < 0.01; c, P < 0.001.