Table 7. Dual energy X-ray absorption (DXA) analysis of bone- and weight-related parameters in line Pou3f3L423P.
| Males | Females | |||
|---|---|---|---|---|
| Parameter | Homozygous mutant | Wild-type | Homozygous mutant | Wild-type |
| BMD (mg/cm2) | 54 ± 6 b | 63 ± 5 | 54 ± 5 | 61 ± 6 |
| BMC (mg) | 548 ± 79 c | 883 ± 246 | 522 ± 196 a | 804 ± 249 |
| Bone content (%) | 2.0 ± 0.3 a | 2.4 ± 0.6 | 2.0 ± 0.4 | 2.3 ± 0.4 |
| Body length (cm) | 9.9 ± 0.2 b | 10.3 ± 0.2 | 9.9 ± 0.4 a | 10.3 ± 0.4 |
| Body weight (g) | 28.1 ± 2.7 c | 36.3 ± 3.3 | 25.2 ± 4.8 c | 33.8 ± 6.3 |
| Fat mass (g) | 5.8 ± 1.8 c | 15.1 ± 5.5 | 6.6 ± 4.7 b | 14.7 ± 7.3 |
| Lean mass (g) | 16.0 ± 1.2 | 14.0 ± 4.0 | 12.9 ± 1.3 | 12.7 ± 3.2 |
BMD, bone mineral density; BMC, bone mineral content.
Analysis was done at the age of 19 weeks. No. per genotype and sex: n = 8–16. Data are presented as mean ± standard deviation. Significance vs. wild-type controls: a P < 0.05, b P < 0.01, c P < 0.001.