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. 2016 Mar 22;11(3):e0149394. doi: 10.1371/journal.pone.0149394

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© 2016 Kong et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — (A, B) Seven-week-old SD rats (200 g) were treated with the appropriate substance by i.p. injection for 2 weeks, and then common carotid arteries (CCAs) from the rats were balloon-injured. The chosen substance was injected for another 4 weeks, and then the rats were sacrificed for (A) hematoxylin and eosin staining of CCAs. The graph shows the percentage of neointima area in SD rats from each group (n = 7). Measurements were performed using Scion Image software. (B) Immunohistochemistry staining of rat aortas show CD31, VCAM-1, and ICAM-1 production in the linings of the aorta from the same tissues used in Fig 6A. Data are presented as the mean ± SEM. Values represent the mean ± SEM of three experiments; *** indicates p < 0.001 compared to the sham group. ### indicates p < 0.001 compared to the vehicle group.