Table 3.

Changes in brain activity in response to emotional words and emoticon faces

Talairach code			Voxels	FDR <0.05	Regions
x	y	z
Game-CBT: emotional words (baseline <6 weeks)
50	−39	−3	210	P<0.0012	G1. Right temporal lobe BA 37
−32	−46	51	191	P<0.0012	G2. Left superior parietal lobule, BA 7
−50	−51	8	186	P<0.0012	G3. Left superior temporal gyrus, BA 39
Game-CBT: emotional words (baseline >6 weeks)
None
Game-CBT: facial emoticons (baseline <6 weeks)
11	0	40	204	P<0.0017	G4. Right cingulate gyrus, BA 24
−21	39	22	194	P<0.0017	G5. Left medial frontal gyrus, BA 9
−19	−64	−19	182	P<0.0017	G6. Left cerebellum, posterior lobe
−39	−68	−14	180	P<0.0017	G7. Left fusiform gyrus, BA 19
−39	6	9	177	P<0.0017	G8. Left insular and sublobar
Game-CBT: facial emoticons (baseline <6 weeks)
None
Offline-CBT: emotional words (baseline >6 weeks)
6	−40	30	321	P<0.0009	O1. Right cingulate gyrus, BA 31
−42	−30	24	292	P<0.0009	O2. Left parietal lobe white matter
Offline-CBT: emotional words (baseline >6 weeks)
None
Offline-CBT: facial emoticons (baseline <6 weeks)
19	42	2	115	P<0.0093	O3. Right anterior cingulate, BA 32
−2	34	−2	83	P<0.0093	O4. Left anterior cingulate, BA 24
−1	−33	26	81	P<0.0093	O5. Left cingulate gyrus, BA 23
Offline-CBT: facial emoticons (baseline >6 weeks)
17	27	38	212	P<0.0021	O6. Right medial frontal gyrus, BA 6
−6	34	46	192	P<0.0021	O7. Left superior frontal gyrus, BA 8
−34	−65	46	175	P<0.0021	O8. Left superior parietal lobe, BA 7

Note: The cluster significance level of P<0.05 was estimated through Monte Carlo simulations using the BrainVoyager Cluster Threshold plugin.

Abbreviations: BA, Brodmann area; CBT, cognitive behavior therapy; FDR, false discovery rate.