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. 2016 Mar 16;9:1559–1569. doi: 10.2147/OTT.S100050

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© 2016 Ma and Yu. This work is published and licensed by Dove Medical Press Limited

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USP7 could increase the viability of malignant ovarian cell lines.

Notes: Cell viability was detected by the PrestoBlue Cell Viability Reagent at different time points. The siRNA-transfected OVCAR3 cells showed decreased cell viability compared with blank control and the ncRNA-OVCAR3 (A and B), while the overexpression of UPS7 can significantly increase the cell viability (C and D). ^*Statistically significant.

Abbreviations: USP7, ubiquitin-specific protease 7; ncRNA, negative control siRNA; siUSP7, siRNA of USP7; si, small interfering.