Fig 6. Switching STDP learning rules by inhibition of dendritic signals in a compartment-specific manner.

Results are presented in the same format as in Fig 3A. For each synaptic location, a somatic step current was paired 100 times at 1 Hz with the synaptic activation at different Δt, to simulate a pairing protocol, and to measure the resulting plasticity rule. Inhibition was placed at different locations on the dendritic tree, inhibition onset was 1.5 ms after stimulation onset, rise and decay time constants were 0.5 ms and 5 ms, respectively, the maximum conductance amounted to 50 nS. Synaptic change was normalized to its maximum. A: No inhibition. B: Distal inhibition on the apical dendrite led to a flat STDP window in the distal synapse. C: Proximal inhibition on the apical dendrite caused zero synaptic change in both oblique and distal synapses. D: Proximal inhibition on the basal dendrite abolished STDP in the basal synapse.