Table 1. Baseline and follow-up demographics and clinical characteristics of patients with primary progressive multiple sclerosis.

	PPMS patients at baseline (n = 25)	PPMS patients at 1 year follow-up (n = 20)	*p
Female/male	13/12	12/8	-
Age (years)	50.6± 10.4	50.4 ± 11.1	-
Disease duration (years)	8.7± 4.8	9.1 ± 5.0	-
EDSS score median (range)	4 (1.5–6)	4 (2–6)	n.s.
25FWTsec	7.4 ± 2.2	7.1 ± 2.1	n.s.
NHPTsec	31.1 ± 11.7	33.7 ±18.3	n.s.
SDMT raw score	36 ± 14.3	36.5 ± 13.6	n.s.

Values in table are: mean +/- standard deviation; PPMS = primary progressive multiple sclerosis; EDSS = Expanded Disability Status Scale; 25FWT = 25 Feet Walk Test; NHPT = Nine Hole Peg Test; SDMT = Symbol Digit Modality Test

*Wilcoxon signed-rank test p<0.05 in 20 patients with PPMS between baseline and follow-up.