Table 3. Significant baseline and follow-up correlations between CL counts and volumes and clinical variables (without correction for age and gender).

	Baseline				Follow-up
	PPMS (n = 25)				PPMS (n = 20)
	SDMT		NHPT		EDSS		SDMT		NHPT		25FWT
CL number	r	p	r	p	r	p	r	p	r	p	r	p
DIR Total CL	-0.50	0.02	0.42	0.04	n.s.	n.s.	-0.62	0.003	0.51	0.02	0.47	0.04
PSIR Total CL	-0.52	0.01	n.s.	n.s.	n.s.	n.s.	-0.69	0.001	0.47	0.04	0.45	0.05
DIR IC	-0.47	0.02	0.41	0.04	n.s.	n.s.	-0.56	0.01	0.54	0.01	n.s.	n.s.
PSIR IC	-0.59	0.003	0.60	0.002	n.s.	n.s.	-0.82	<0.0001	0.71	<0.0001	n.s.	n.s.
DIR LC	-0.50	0.02	n.s.	n.s.	0.46	0.04	-0.55	0.01	0.46	0.04	0.52	0.02
PSIR LC	-0.50	0.02	n.s.	n.s.	n.s.	n.s.	-0.61	0.005	n.s.	n.s.	0.48	0.03
CL volume
DIR Total CLV	-0.44	0.03	n.s.	n.s.	0.50	0.03	-0.53	0.02	n.s.	n.s.	0.50	0.03
PSIR Total CLV	-0.50	0.01	n.s.	n.s.	n.s.	n.s.	-0.66	0.002	n.s.	n.s.	0.50	0.04
DIR ICV	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.	-0.52	0.02	n.s.	n.s.	n.s.	n.s.
PSIR ICV	-0.54	0.01	0.64	0.01	n.s.	n.s.	-0.75	<0.0001	0.78	<0.0001	n.s.	n.s.
DIR LCV	-0.48	0.02	n.s.	n.s.	0.55	0.012	-0.49	0.03	n.s.	n.s.	0.52	0.02
PSIR LCV	-0.47	0.02	n.s.	n.s.	0.52	0.02	-0.55	0.01	n.s.	n.s.	0.52	0.02

r and p derived from Spearman rank correlations coefficient, DIR = double inversion recovery; PSIR = phase sensitive inversion recovery; PPMS = primary progressive multiple sclerosis; CL = cortical lesions; IC = intracortical lesions; LC = leucocortical lesions; JC = juxtacortical lesions; CLV = cortical lesion volume; ICV = intracortical lesion volume; LCV = leucocortical lesion volume; JCV = juxtacortical lesion volume. EDSS = Expanded Disability Status Scale; SDMT = Symbol Digit Modality Test; NHPT = Nine Hole Peg Test; 25FWT = 25 Feet Walk Test.