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. Author manuscript; available in PMC: 2017 Jan 18.
Published in final edited form as: Angew Chem Int Ed Engl. 2015 Dec 3;55(3):1070–1074. doi: 10.1002/anie.201507494

Table 2.

Scope of Diarylmethanes in Allylic Alkylation Reactions.[a]

graphic file with name nihms765615u3.jpg
Entry Ar Base Ratio (1:base:2a) Product Yield (%)
1 Ph KHMDS 1:5:3 3aa 88
2 4-C6H4-F KHMDS 1:4:3 3ba 67
3 4-C6H4-Cl NaHMDS 1:5:3 3ca 98
4 4-C6H4-Br NaHMDS 1:5:3 3da 89
5 4-C6H4-Me KHMDS 1:5:3 3ea 61
6 2-C6H4-Me KHMDS 1:5:3 3fa 65
7 graphic file with name nihms765615t1.jpg LiOtBu 1:1.5:1.2 3ga 83
[a]

Reactions conducted on a 0.1 mmol scale.

[b]

Isolated yield after chromatographic purification.