Table 3.
| ||||||
---|---|---|---|---|---|---|
Entry | Ar | Ar′ | Base | Ratio (4:base:2a) | Product | Yield (%) |
1 | 2-Py | Ph | NaHMDS | 1:2:1.2 | 5aa | 91 |
2 | 3-Py | Ph | NaHMDS | 1:3:1.2 | 5ba | 91 |
3 | 4-Py | Ph | LiHMDS | 1:2:1.2 | 5ca | 93 |
4 | 3-Py | 3-Py | LiHMDS | 1:3:1.2 | 5da | 90 |
5 | 2-thienyl | Ph | NaHMDS | 1:2:1.2 | 5ea | 82 |
| ||||||
6 | LiHMDS | 1:3:1.2 | 5fa | 81 |
Reactions conducted on a 0.1 mmol scale.