Table 4.
| ||||||
---|---|---|---|---|---|---|
Entry | Ar | Ar′ | Base | Ratio (4:base:2a) | Product | Yield (%) |
1 | 2-Py | Ph | KHMDS | 1:5:3 | 6aa | 84 |
2 | 3-Py | Ph | KHMDS | 1:5:3 | 6ba | 78 |
3 | 4-Py | Ph | KHMDS | 1:5:3 | 6ca | 75 |
4 | 2-thienyl | Ph | KHMDS | 1:5:3 | 6da | 83 |
| ||||||
5 | KOtBu | 1:5:3 | 6ea | 90 | ||
6 | NaHMDS | 1:5:3 | 6fa | 89 |
Reactions conducted on a 0.1 mmol scale.