TABLE 4.

CRs Univariate and Multivariate Analyses of Predictors of Exclusion From LT

Predictor Variables	HR (95% CI)	P Value
Univariate analysis
Age at T1 diagnosis (per year)	0.99 (0.95-1.04)	0.73
Sex, female	0.68 (0.23-2.00)	0.49
Race/ethnicity (versus Caucasian)
Hispanic	1.90 (0.57-6.35)	0.30
African American	1.64 (0.22-12.24)	0.63
Asian	0.96 (0.32-2.90)	0.94
Diagnosis of liver disease (versus HCV)
Alcohol	1.99 (0.41-9.73)	0.40
HBV	0.91 (0.29-2.81)	0.86
NASH	0.47 (0.06-3.81)	0.48
CTP score (per point)	0.92 (0.68-1.24)	0.60
MELD score (per point)	0.95 (0.82-1.11)	0.55
Tumor size at T1 diagnosis (per cm)	1.64 (0.29-9.37)	0.58
AFP at T1 diagnosis
≥20 (versus<20)	2.09 (0.72-6.11)	0.18
≥100 (versus<100)	2.07 (0.58-7.30)	0.26
≥500 (versus<500)	6.90 (1.66-28.70)	0.008
Hypovascularity	1.30 (0.31-5.46)	0.72
Absence of washout	0.82 (0.27-2.47)	0.72
Rapid tumor progression*	4.12 (1.61-10.53)	0.003
Multivariate analysis
AFP≥500 (versus<500)	12.69 (2.82-57.01)	0.001
Rapid tumor progression*	5.68 (2.20-14.64)	<0.001

^*Defined as>1 cm increase in total tumor diameter over 3 months.