Table 1.
Efficacy |
nab-P + Gem |
Gem |
||||||
---|---|---|---|---|---|---|---|---|
PET response |
RRR or HRa (95% CI) | P value | PET response |
RRR or HRa (95% CI) | P value | |||
Yes (N = 93) | No (N = 37) | Yes (N = 67) | No (N = 60) | |||||
ORR by RECIST | 37% | 16% | 2.3 (1.03–4.92) | 0.023 | 18% | 3% | 5.4 (1.25–23.04) | 0.009 |
Median PFS | 7.5 months | 5.3 months | 0.63 (0.36–1.11) | 0.110 | 5.6 months | 3.6 months | 0.39 (0.24–0.66) | <0.001 |
Median OS | 11.5 months | 8.0 months | 0.85 (0.54–1.32) | 0.464 | 10.9 months | 6.3 months | 0.43 (0.29–0.65) | <0.001 |
aRRR = ORRPET response/ORRno PET response; HR = HRPET response/no PET response.
Gem, gemcitabine; HR, hazard ratio; nab-P, nab-paclitaxel; ORR, overall response rate; OS, overall survival; PET, positron emission tomography; PFS, progression-free survival; RECIST, Response Evaluation Criteria In Solid Tumors; RRR, response rate ratio.