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Relationship between the median effective dose that produces loss of righting reflexes in rats (ED50) predicted by our comparative molecular field analysis (CoMFA) model and that determined experimentally in rats. The dashed line is a linear fit of the logarithm-transformed data. The slope of the fitted line was 0.972 ± 0.036 and the coefficient of determination (r2) was 0.97. The name and structure of each numbered compound is given in Table 1.
