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Relationship between the half-maximal direct activating concentration of etomidate and etomidate analogues (EC50) and their octanol-water partition coefficients. The dashed line is a linear fit of the logarithm-transformed data. The slope of the fitted line was 0.13 ± 0.20 μM and the coefficient of determination (r2) was 0.019. The name and structure of each numbered compound is given in Table 1.
