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. Author manuscript; available in PMC: 2017 Feb 5.
Published in final edited form as: Differentiation. 2016 Feb 5;91(1-3):42–49. doi: 10.1016/j.diff.2016.02.001

Fig. 2.

Fig. 2

Early deletion of β-catenin in developing liver impairs hepatic morphogenesis but is compatible with biliary differentiation. Embryos with inactivation of β-catenin starting around E10.5 (Foxa3-Cre/βCatKO) showed perturbed liver architecture and differentiation of hepatocytes at E17.5; the number of HNF4α+ cells (arrowheads) was reduced. Biliary cells expressed the expected biliary markers but formed an increased number or irregularly-shaped luminal structures. βCat, β-catenin; Ecad, E-cadherin; hd, hepatic duct; OPN, osteopontin; pv, portal vein; *, lumen of ductal structure; scale bar, 100 μm.