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. Author manuscript; available in PMC: 2017 Feb 5.
Published in final edited form as: Differentiation. 2016 Feb 5;91(1-3):42–49. doi: 10.1016/j.diff.2016.02.001

Fig. 4.

Fig. 4

Beta-catenin is dispensable for cell fate determination of cholangiocyte precurors. Lineage tracing of the cholangiocyte precusors labeled at E14.5 (Sox9-CreER/βCatKO/Rosa26ReYFP) showed that these cells generate bile ducts and periportal hepatocytes in postnatal livers, in the presence (Sox9-CreER/βCatWT/Rosa26ReYFP) or absence (Sox9-CreER/βCatKO/Rosa26ReYFP) of β-catenin. Periportal hepatocytes derived from the wild-type or β-catenin-deficient cholangiocyte precursors expressed carbamoyl-phosphate-synthetase-1 (CPS1), but not glutamine synthetase (GS). βCat, β-catenin; cv, central vein; Ecad, E-cadherin; pv, portal vein; YFP, yellow fluorescent protein; *, lumen of bile duct, scale bar (200 μm).