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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Genesis. 2016 Feb 5;54(3):129–135. doi: 10.1002/dvg.22918

Figure 3.

Figure 3

Nrl-Cre mice have no detectable functional or morphological defects. Whole animal electroretinograms (ERGs) of Nrl-Cre mice and Cre negative littermate controls were performed at 1 Month (a–c) and 4 Months of age (d–f). Responses of Nrl-Cre mice were no different from Cre negative littermate controls for all physiological tests at 1 month of age. 4 month old Nrl-Cre mice showed marginal but significant increases in dark-adapted A wave amplitudes (d) and light-adapted B wave amplitudes (f) responses but no individual light intensities were significantly increased. Dark-adapted B wave amplitudes at 4 months were not significantly different. Nrl-Cre (h,j) and Cre Negative littermate control (g, i) retinal cross-sections were stained with hematoxylin and eosin (H&E) at 1 month (g,h) and 4 months (i,j). Two-way ANOVA with Sidak’s multiple comparisons. p<0.05 CI: 95% Error bars = SEM.