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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: J Mol Med (Berl). 2015 Oct 21;94(3):259–265. doi: 10.1007/s00109-015-1353-4

Fig. 1. Molecular and cellular mechanism of PCa dormancy.

Fig. 1

A schematic diagram summarizing the current evidence of molecular and cellular events in maintaining dormancy in PCa cells. Gene expression signature was adopted from references [6, 27]. Red: upregulated; green: downregulated. * in breast cancer; # in head and neck squamous carcinoma; ^ in ovarian cancer. TSP-1: thrombospondin-1; GAS6: Growth arrest-specific 6; TBK1: TANK-binding kinase 1; BMP7: Bone morphogenetic protein 7.; TGFβ: transforming growth factor beta; CXCL12: C-X-C motif chemokine 12; Src: Proto-oncogene tyrosine-protein kinase Src.