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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Hippocampus. 2015 Oct 19;26(4):455–471. doi: 10.1002/hipo.22535

Figure 4. Hippocampal-dependent transfer learning performance in 3 and 6 month old APPswePS1 and NTg control mice.

Figure 4

(A) Bar graph shows that mean number of trials (+SEM) required to reach criterion performance on the shaping problem prior to testing in the transfer learning task did not differ by age or genotype. (B & C) Bar graphs show that mean number of trials to reach criterion (+SEM) on Problem Set 1 (B) and Problem Set 2 (C) in the learning phase of the transfer task did not differ by age or genotype. (D) In contrast, 6 mo. but not 3 mo. APPswePS1 mice made significantly more incorrect choices (errors +SEM) on the transfer phase of the task relative to their respective age-matched NTg controls. In addition, 6 mo. APPswePS1 mice made significantly more errors than 3 mo. APPswePS1 mice. See text for statistical analysis. * p < 0.05, **p < 0.01.