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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Allergy. 2016 Feb 4;71(4):463–474. doi: 10.1111/all.12827

Figure 3.

Figure 3

Schematic diagram of the proposed mechanisms for miR-511-3p in modulating allergic inflammation in asthma. MRC1 transcribes the primary intronic miR-511, and followed by the miRNA machinery to generate the mature miR-511-3p sequence. The miR-511-3p can directly targets several genes (e.g., ROCK2, PTEN, and LTBP1) and shape the balance of M1 and M2 macrophage polarization and skew the immune response. In addition, miR511-3p may also modulate the expression of several indirect targets. MRC1, macrophage receptor, AGO, Argonaut.