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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: FEBS J. 2015 Nov 12;283(6):986–992. doi: 10.1111/febs.13569

Fig. 4. Model for polypeptide chain movement by Pex1/Pex6.

Fig. 4

A polypeptide chain moves through the D1 ring into the D2 ring. Pairs of Pex1/Pex6 ATPase domains in the D2 ring undergo a tilting motion in response to ATP hydrolysis, dragging the polypeptide chain through the central pore. At any given moment, one of the Pex1/Pex6 pair is tilted (shown in black), while the other two pairs are not (shown in grey). The tilting motion occurs in a circular manner around the ring.