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. Author manuscript; available in PMC: 2017 May 3.
Published in final edited form as: Neuroscience. 2016 Jan 6;321:99–107. doi: 10.1016/j.neuroscience.2015.12.061

Table 2.

Enigma of the biological roles of DISC1

Enigma Strategy to address enigma
Multiple Disc1 isoforms

  • Complex splicing events

  • Interchromosomal protein fusion

 Identification and functional characterization of each isoform

  • Detection of splicing and fusion events

  • Expression profiling (cell type-specific, brain region-specific and developmental expression pattern)

  • Biochemical function (specific loss of binding partners, propensity to aggregation)
Developmental compensation Comprehensive phenotypic characterization
Comparison among mouse models