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. Author manuscript; available in PMC: 2017 Mar 3.
Published in final edited form as: J Clin Periodontol. 2016 Mar 3;43(3):238–249. doi: 10.1111/jcpe.12507

Figure 3. Decreased GCF levels of pro-inflammatory and pro-osteoclastogenic mediators in NHPs with natural periodontitis after local treatment with Cp40 three times weekly.

Figure 3

At the indicated time-points, GCF was collected from monkeys with natural periodontitis which were treated three times weekly for 6 weeks with Cp40 in the maxilla (“Cp40”) but not in the mandible (“Untreated”). Total cytokine or mediator content (A, IL-1β; B, IL-6; C, IL-8; D, IL-17; E, RANKL; F, OPG; G, C3a; H, C5/C5a) in the eluted GCF samples was measured using a Bio-Plex system or ELISA (C3a only). Data are means ± SD (n = 10 monkeys). *P < 0.05; **P < 0.01 compared to baseline (one-way repeated-measures ANOVA and Bonferroni’s multiple comparisons test).