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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: J Mol Med (Berl). 2016 Feb 2;94(3):277–286. doi: 10.1007/s00109-016-1386-3

Fig. 4.

Fig. 4

IL-10 is necessary for the decrease in atherosclerosis in low ambient oxygen. a Effect of IL-10 on aortic atherosclerotic plaque development in ApoE−/− mice chronically adapted to hypoxia. Mice of the indicated genotypes were maintained in either 21% O2 or 10% O2 for 22 wk. Atherosclerosis was quantified by staining whole aorta with Sudan IV (red, representative images). Scale bars: 1 mm. b Representative cross sections of the aortic root at the valve leaflet level were stained with H&E to show differences in the arterial wall (neointima and smooth muscle layers) depending on ambient oxygen exposure and IL-10 genotype. Scale bars: 200 μm. c Plasma IFN-γ levels were measured as marker of inflammatory activity in mice exposed to 10% or 21% O2 for 22 wk (n=5–7). **p< 0.01, one-way ANOVA with a Tukey posttest.