Table 1.
Effect of ambient oxygen on cardiometabolic factors in ApoE−/− mice
| Parameters | 21% O2 | 10% O2 | P-value |
|---|---|---|---|
| Body weight (g) | 24.2 ± 0.3 | 24.0 ± 0.4 | 0.7 |
| Fat Mass (%) | 10.2 ± 0.8 | 9.0 ± 0.2 | 0.4 |
| Systolic blood pressure (mmHg) | |||
| Dark | 131.9 ± 10.3 | 131.9 ± 4.8 | 1 |
| Light | 110.3 ± 3.6 | 118.9 ± 4.7 | 0.2 |
| Diastolic blood pressure (mmHg) | |||
| Dark | 99.6 ± 7.0 | 105.4 ± 4.0 | 0.5 |
| Light | 79.4 ± 5.5 | 91.5 ± 3.3 | 0.1 |
| Total cholesterol (mg/dL) | 384.4 ± 19.1 | 536.5 ± 35.4 | 0.009 |
| HDL (mg/dL) | 166.9 ± 9.6 | 178.5 ± 12.5 | 0.5 |
| LDL/VLDL (mg/dL) | 247.2 ± 15.0 | 351.7 ± 38.0 | 0.049 |
| Triglycerides (mg/dL) | 55 ± 10.7 | 157 ± 33.9 | 0.001 |
| OxLDL (μmole/ml) | 6.2 ± 0.1 | 6.3 ± 0.2 | 0.6 |
Female ApoE−/− mice were exposed to the indicated oxygen concentration for 22 wk after which plasma lipids, body weight and composition were determined (n = 5–22). Blood pressure was monitored by telemetry during 12-h dark and light cycles after a 5-wk acclimation period to 10% O2 (n = 4).