(a) Percent signal change (mean ± SEM) in risky vs. safe brain activation at baseline and revisit. *Binge-drinking adolescents showed decreased risky vs. safe brain activation at revisit compared to baseline. #At revisit, binge-drinking adolescents showed decreased risky vs. safe brain activation compared to controls. (b) Drinking days in the past 3 months, and (c) heavy drinking days in the past 3 months1, were negatively related to the change in risky vs. safe percent signal change, between revisit and baseline, in binge-drinking adolescents.