Table 2. Whole-Brain Analysis of BOLD response in Binge-Drinking and Alcohol-Naïve Youth.

Anatomical Location	Side	x	y	z	Volume (voxels)	F-value	Partial Eta Squared
Group by Time Interaction
No significant clusters found
Main Effect of Group
Cluster 1: IPL, SMG, STG	L	-58	-46	41	251	6.41	0.21
Cluster 2: IFG, STG	L	-28	22	-27	215	7.69	0.24
Cluster 3: MTG, STG	L	-67	-25	-9	149	7.78	0.24
Cluster 4: STG, MTG	R	67	-31	2	125	6.59	0.22
Main Effect of Time
Cluster 1: Cerebellum, FG, MOG, IOG	L	-28	-76	-15	555	6.52	0.21
Cluster 2: SFG, MFG	R	28	46	38	306	8.60	0.26
Cluster 3: PostCG, IPL, PreCG	L	-46	-34	56	305	7.58	0.24
Cluster 4: ACG, MeFG, SFG	R/L	-1	22	38	218	6.82	0.22
Cluster 5: MOG, Cuneus	R	46	-73	-3	198	7.40	0.24
Cluster 6: Thalamus, LN	L	-1	-10	-9	131	6.81	0.22

Clusters with significant interactions or main effects in whole-brain analysis of risky vs. safe selection brain activation. Presented for each cluster is the anatomical location of significant voxels, the peak voxel coordinates in Talairach space, the size of the cluster, the corresponding F-value and effect size.

R, right; L, left; ACG, anterior cingulate gyrus; FG, fusiform gyrus; IFG, inferior frontal gyrus; IOG inferior occipital gyrus; IPL, inferior parietal lobule; LN, lentiform nucleus; MeFG, medial frontal gyrus; MFG, middle frontal gyrus; MOG, middle occipital gyrus, MTG, middle temporal gyrus; PostCG, postcentral gyrus; PreCG, precentral gyrus; SFG, superior frontal gyrus; SMG, supramarginal gyrus; STG, superior temporal gyrus.