. 2016 Mar 16;77(2):227–237. doi: 10.15288/jsad.2016.77.227

Table 3.

Association between nicotine phenotypes and rs3743078 in lifetime smokers (n = 662)

	Craving			CPD			FTND
Variable	M		SD	M		SD	M		SD
GG/CG (n = 615)^a	3.8		2.5	24.1		15.9	3.5		2.5
CC (n = 47)	2.7		2.5	18.2		12.8	2.4		2.1
	b	[95% CI]	p	b	[95% CI]	p	b	[95% CI]	p
Linear regression analysis^b	1.16	[0.41, 1.91]	.0025	6.31	[1.85, 10.78]	.0057	1.12	[0.40, 1.84]	.0024

Notes: SD = standard deviation; CI = confidence interval; craving = craving scale, lifetime, with higher values indicating greater craving (range: 0–8); CPD = cigarettes per day, during period of heaviest smoking (range: 1–80); FTND = Fagerström Test for Nicotine Dependence, lifetime (range: 0–8); b = regression coefficient; p values are reported to allow evaluation of significance, using a p value of .0068 to adjust for multiple testing.

^{^a}

Genotypes GG (n = 351) and CG (n = 264) were combined into one group because means for the phenotypes were virtually the same: craving, GG M = 3.81 (SD = 2.56), CG M = 3.83 (SD = 2.55); CPD, GG M = 24.16 (SD = 16.23), CG M = 24.06 (SD = 15.49); FTND, GG M = 3.48 (SD = 2.55), CG M = 3.48 (SD = 2.37).

^{^b}

Adjusted for demographics: age, sex, ethnicity (immigrant from former Soviet Union status).