Fig. 1.

Simulated stool sample: comparison of three different sequencing platforms. With extremely high CCS-reads quality, the results obtained using PacBio are 100% specific and sensitive. On the contrary, both IonTorrent PGM and Illumina MiSeq report several false positive and miss to identify one variant (Supplementary Table 1, Supplementary Table 2).

Simulated stool sample: comparison of three different sequencing platforms. With extremely high CCS-reads quality, the results obtained using PacBio are 100% specific and sensitive. On the contrary, both IonTorrent PGM and Illumina MiSeq report several false positive and miss to identify one variant (Supplementary Tables 1 and 2).