Fig. 1.

Sequence identity matrix and 3D-models of allergenic protein families. a Ole e 1-like proteins and structure of Pla l 1.0101 (4Z8W), b pectate lyases and model of Amb a 1.0101 (template 1PXZ), and c lipid transfer proteins and model of Art v 3.0201 (template 2B5S). Multiple sequence alignments performed in Clustal Omega. Models were generated using Swiss-Model (www.swissmodel.expasy.org), and ribbon cartons are shown using UCSF Chimera (www.cgl.ucsf.edu/chimera). Green boxes represent demonstrated IgE cross-reactivity, light green boxes represent potential IgE cross-reactivity based on high sequence identity, red boxes represent no/limited demonstrated IgE cross-reactivity and light red boxes represent no/limited IgE cross-reactivity based on low sequence identity