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. 2016 Mar 15;44(3):553–567. doi: 10.1016/j.immuni.2016.02.020

Figure 2.

Figure 2

Reduced Paneth Cell Numbers and Increased IEC Apoptosis in Ileal Crypts of NEMOIEC-KO Mice

(A and G) Representative images of ileal sections from NEMOIEC-KO and NemoFL, NEMOtamIEC-KO, and NemoFL littermates 8 days after tamoxifen administration stained with H&E or immunostained for cl. casp3 or lysozyme.

(B and K) Graph depicting histopathological scores of ileal sections from NEMOIEC-KO and NemoFL, NEMOtamIEC-KO and NemoFL littermates 8 days after tamoxifen administration (n = 6–9 mice per genotype).

(C, F, J, and L) Graphs depicting mRNA levels of the indicated genes in the ileum of NEMOIEC-KO and NemoFL mice and NEMOtamIEC-KO and NemoFL littermates 8 days after tamoxifen administration (n = 5–8 mice per genotype).

(D and H) Graphs depicting percentage of crypts with cl. casp. 3 stained IECs on ileal sections from NEMOIEC-KO and NemoFL mice and NEMOtamIEC-KO and NemoFL littermates 8 days after tamoxifen administration (n = 6–8 mice per genotype).

(E and I) Graphs depicting Paneth cell scores of ileal sections from NEMOIEC-KO and NemoFL mice and NEMOtamIEC-KO and NemoFL littermates 8 days after tamoxifen administration (n = 6–9 mice per genotype).

Scale bars represent 100 μm. See also Figure S2.