Table 4.

TBOA has a greater effect on astrocyte EFS-evoked Ca²⁺ signals in WT mice than in R6/2 mice

	Control	+TBOA	p	Fold change from control to TBOA	n (cells, mice)
WT somata
Peak dF/F	0.18 ± 0.05	2.36 ± 0.60	0.00489	13.1	10–13, 4
R6/2 somata
Peak dF/F	0.98 ± 0.40	3.13 ± 0.57	0.01795	3.2	12–15, 4
WT branches
Peak dF/F	0.30 ± 0.04	1.83 ± 0.14	<0.00001	6.1	10–13, 4
R6/2 branches
Peak dF/F	0.70 ± 0.10	0.82 ± 0.07	0.00845	1.2	12–15, 4

Data are from experiments such as those illustrated in Figure 7, F and H, but summarized here for R6/2 and noncarrier controls (WT). TBOA significantly increased the EFS-evoked Ca²⁺ signals in WT and R6/2 mice somata, but the fold changes were greater in WT. For the experiments shown in this table, the fold changes were calculated from the average data because the control and +TBOA experiments were not always from the same cells. Nonetheless, the trend for greater effects of TBOA in WT mice was very clear and consistent with the data shown in Tables 2 and 3.