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Hindbrain administration of fluorescently labeled Ex-4 produces energy balance effects comparable to those of unlabeled Ex-4. a, b, Fourth cerebroventricle administration of Ex-4 (0.3 μg) reduces chow intake (a) and body weight gain (b) in rats (n = 4); an equal dose of fluoro-Ex-4 given at the fourth cerebroventricle causes similar suppression of feeding and body weight gain. The key for a applies to both a and b. *p < 0.05 compared with vehicle. Data are shown as the mean ± SEM.
