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. 2016 Mar 23;36(12):3531–3540. doi: 10.1523/JNEUROSCI.3579-15.2016

Figure 3.

Figure 3.

The internalization of peripherally administered fluoro-Ex-4 in NTS cells is blocked by fourth cerebroventricle pretreatment with a GLP-1R antagonist. A, B, While uptake of fluoro-Ex-4 (10 μg/kg, i.p.) was observed in NTS astrocytes and neurons of rats given a fourth cerebroventricle pretreatment with vehicle (A; n = 3), central pretreatment with Ex-9 (100 μg) blocked this effect (B; n = 4; see also Movie 2). Fluoro-Ex-4 is shown in green, GFAP-positive cells are shown in red, and NeuN-positive neurons are shown in blue. The smaller insets at the top of each panel depict representative NTS-containing coronal sections at 20× magnification. The boxed area of each inset was magnified to 63× and a further 2–3× optical zoom was applied to generate the large images. cc, Central canal.