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. 2016 Mar 23;36(12):3588–3599. doi: 10.1523/JNEUROSCI.3682-15.2016

Figure 1.

Figure 1.

Bidirectional modulation of the dorsal hippocampus via hSyn–DREADDs affects LTM processes. A, Subthreshold training and testing paradigm for NOR tasks. B, Training and testing DIs of hSyn–GFP (white) and hSyn–HM3D (blue), shown as mean ± SEM. i, Mean DI for OLM training. ii, Mean DI for OLM testing. iii, Mean DI for ORM training. iv, Mean DI for ORM testing. C, Immunohistochemistry against DAPI (blue), GFP (green), and HA (red) in hSyn–GFP or hSyn–HM3D infused dorsal hippocampus. D, Normalized RT-qPCR measuring relative c-fos:GAPD expression in hSyn–GFP (white) and hSyn–HM3D (blue). E, Threshold training and testing paradigm for NOR tasks. F, Training and testing DIs of hSyn–GFP (white) and hSyn–HM4D (red), shown as mean ± SEM. i, Mean DI for OLM training. ii, Mean DI for OLM testing. iii, Mean DI for ORM training. iv, Mean DI for ORM testing. G, Immunohistochemistry against DAPI (blue), GFP (green), and HA (red) in hSyn–GFP or hSyn–HM4D infused dorsal hippocampus. H, Normalized RT-qPCR measuring relative c-fos:GAPD expression in hSyn–GFP (white) and hSyn–HM4D (red). For HM3D OLM and ORM experiments, n = 10 for hSyn–GFP and n = 11 for hSyn–HM3D. For HM4D OLM experiments, n = 11 for hSyn–GFP and n = 12 for hSyn–HM4D. For HM4D ORM experiments, n = 12 for hSyn–GFP and n = 12 for hSyn–HM4D. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.