Figure 5.

a, The unsupervised learning test arena is a large open field divided by walls into 4 chambers, all accessible by small entrances in each dividing wall, and a black box into which mice can escape. b, Aged mice treated with ETP69 (10 mg/kg, i.p.) showed a significant decrease in habituation/exploration (as measured by distance traveled) on day 2 compared with day 1. Aged control mice spent equal time(s) exploring the test arena on both day 1 and day 2. Habituation was measured over 30 min, and data shown are in 5 min bins. *p < 0.05, significant difference between habituation/exploration on day 1 and day 2 at the specified time points (Tukey's t test). n = 5 or 6/group. c, Graph represents the total distance traveled over 30 min on day 1 and day 2 following administration of ETP69 (10 mg/kg, i.p) or vehicle. *p < 0.05, significant decrease in total distance traveled in 30 min between day 1 and day 2 (Tukey's t test). Data are mean ± SEM; n = 5 or 6/group.