Fig. 8.

Deferoxamine reduces iron deposition, hydroxyl radical generation and infarct volume in the neonatal rat brain exposed to hypoxia-ischemia. P7 neonatal rats were given deferoxamine (200 mg/kg I.P.) immediately after HI. After HI 8 h the rat brains were removed, iron deposition (A), hydroxyl radical generation (B), and infarct volume (C) were all determined in the right hemisphere. The HI mediated increase in iron deposition (A) and hydroxyl radical generation (B) are prevented by deferoxamine. This correlates with a reduction in infarct volume (C). *P<0.05 vs. sham, †P<0.05 vs. HI+vehicle.