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. 2016 Mar 22;352:i1209. doi: 10.1136/bmj.i1209

Table 4.

Multivariable adjusted hazard ratios (HR) and 95% confidence intervals of mortality according to score on Japanese food guide (lower score=lower adherence=lower quality diet)

Fourths of score 10 point increment P trend*
1 2 3 4
Mean (SD) score 34.2 (4.9) 44.1 (2.0) 51.5 (2.3) 60.3 (3.3)
Person years 301 776 261 794 328 105 292 520
Total mortality
No of deaths 3497 2463 2470 1753
Rate/1000 person years 11.6 9.4 7.5 6.0
Age, sex, and area adjusted HR (95% CI)† 1.00 (ref) 0.86 (0.82 to 0.91) 0.80 (0.75 to 0.84) 0.74 (0.70 to 0.80) 0.88 (0.86 to 0.90) <0.001
Multivariable adjusted HR (95% CI)‡ 1.00 (ref) 0.92 (0.87 to 0.97) 0.88 (0.83 to 0.93) 0.85 (0.79 to 0.91) 0.93 (0.91 to 0.95) <0.001
Cancer mortality
No of deaths 1421 995 1016 755
Rate/1000 person years 4.7 3.8 3.1 2.6
Age, sex, and area adjusted HR (95% CI)† 1.00 (ref) 0.89 (0.82 to 0.96) 0.85 (0.78 to 0.93) 0.86 (0.77 to 0.96) 0.92 (0.89 to 0.95) <0.001
Multivariable adjusted HR (95% CI)‡ 1.00 (ref) 0.94 (0.87 to 1.02) 0.94 (0.86 to 1.02) 0.96 (0.87 to 1.07) 0.96 (0.93 to 1.00) 0.053
Cardiovascular disease mortality
No of deaths 843 640 619 458
Rate/1000 person years 2.8 2.4 1.9 1.6
Age, sex, and area adjusted HR (95% CI)† 1.00 (ref) 0.89 (0.80 to 0.99) 0.77 (0.69 to 0.86) 0.72 (0.63 to 0.82) 0.87 (0.83 to 0.91) <0.001
Multivariable adjusted HR (95% CI)‡ 1.00 (ref) 0.97 (0.87 to 1.07) 0.86 (0.77 to 0.97) 0.84 (0.73 to 0.96) 0.93 (0.89 to 0.98) 0.005
Heart disease mortality
No of deaths 445 334 337 226
Rate/1000 person years 1.5 1.3 1.0 0.8
Age, sex, and area adjusted HR (95% CI)† 1.00 (ref) 0.90 (0.78 to 1.04) 0.83 (0.71 to 0.96) 0.73 (0.60 to 0.88) 0.90 (0.84 to 0.96) <0.001
Multivariable adjusted HR (95% CI)‡ 1.00 (ref) 0.97 (0.84 to 1.13) 0.92 (0.79 to 1.08) 0.84 (0.70 to 1.02) 0.96 (0.90 to 1.02) 0.21
Cerebrovascular disease mortality
No of deaths 325 256 240 184
Rate/1000 person years 1.1 1.0 0.7 0.6
Age, sex, and area adjusted HR (95% CI)† 1.00 (ref) 0.89 (0.76 to 1.06) 0.72 (0.60 to 0.86) 0.66 (0.53 to 0.82) 0.82 (0.76 to 0.89) <0.001
Multivariable adjusted HR (95% CI)‡ 1.00 (ref) 0.97 (0.82 to 1.15) 0.81 (0.68 to 0.98) 0.78 (0.63 to 0.97) 0.89 (0.82 to 0.95) 0.002

*Continuous variables of score used to test linear trend with mortality.

†Adjusted for age, sex, and public health centre area.

‡Additionally adjusted for BMI, smoking status, total physical activity, history of hypertension, history of diabetes, history of dyslipidaemia, coffee consumption, green tea consumption, and occupation.