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. 2016 Mar 22;352:i1209. doi: 10.1136/bmj.i1209

Table 5.

Multivariable adjusted hazard ratios (HR) and 95% confidence intervals of mortality according to score on modified Japanese food guide (lower score=lower adherence=lower quality diet)

Fourths of score 10 point increment P trend*
1 2 3 4
Mean (SD) score 38.7 (5.2) 49.6 (2.3) 57.4 (2.3) 66.9 (3.9)
Person years 300 201 285 424 303 951 294 618
Total mortality
No of deaths 3364 2731 2260 1828
Rate/1000 person years 11.2 9.6 7.4 6.2
Age, sex, and area adjusted HR (95% CI)† 1.00 (ref) 0.89 (0.84 to 0.93) 0.76 (0.72 to 0.81) 0.73 (0.68 to 0.78) 0.89 (0.87 to 0.91) <0.001
Multivariable adjusted HR (95% CI)‡ 1.00 (ref) 0.93 (0.89 to 0.98) 0.84 (0.79 to 0.89) 0.82 (0.77 to 0.88) 0.93 (0.91 to 0.95) <0.001
Cancer mortality
No of deaths 1373 1109 936 769
Rate/1000 person years 4.6 3.9 3.1 2.6
Age, sex, and area adjusted HR (95% CI)† 1.00 (ref) 0.91 (0.84 to 0.99) 0.82 (0.75 to 0.90) 0.82 (0.74 to 0.91) 0.93 (0.90 to 0.96) <0.001
Multivariable adjusted HR (95% CI)‡ 1.00 (ref) 0.96 (0.89 to 1.04) 0.90 (0.82 to 0.99) 0.92 (0.83 to 1.02) 0.97 (0.93 to 1.00) 0.06
Cardiovascular disease mortality
No of deaths 813 675 591 481
Rate/1000 person years 2.7 2.4 1.9 1.6
Age, sex, and area adjusted HR (95% CI)† 1.00 (ref) 0.87 (0.78 to 0.96) 0.76 (0.68 to 0.86) 0.71 (0.62 to 0.81) 0.88 (0.84 to 0.92) <0.001
Multivariable adjusted HR (95% CI)‡ 1.00 (ref) 0.93 (0.84 to 1.03) 0.85 (0.76 to 0.96) 0.81 (0.71 to 0.93) 0.93 (0.89 to 0.97) 0.001
Heart disease mortality
No of deaths 433 370 302 237
Rate/1000 person years 1.4 1.3 1.0 0.8
Age, sex, and area adjusted HR (95% CI)† 1.00 (ref) 0.91 (0.79 to 1.05) 0.76 (0.65 to 0.89) 0.70 (0.58 to 0.84) 0.90 (0.85 to 0.95) <0.001
Multivariable adjusted HR (95% CI)‡ 1.00 (ref) 0.97 (0.84 to 1.12) 0.85 (0.72 to 0.99) 0.79 (0.66 to 0.96) 0.95 (0.89 to 1.00) 0.07
Cerebrovascular disease mortality
No of deaths 309 256 247 193
Rate/1000 person years 1.0 0.9 0.8 0.7
Age, sex, and area adjusted HR (95% CI)† 1.00 (ref) 0.83 (0.70 to 0.99) 0.78 (0.65 to 0.93) 0.66 (0.54 to 0.82) 0.84 (0.78 to 0.90) <0.001
Multivariable adjusted HR (95% CI)‡ 1.00 (ref) 0.89 (0.76 to 1.06) 0.88 (0.73 to 1.06) 0.77 (0.62 to 0.96) 0.89 (0.83 to 0.95) 0.001

*Continuous variables of score used to test linear trend with mortality.

†Adjusted for age, sex, and public health centre area.

‡Additionally adjusted for BMI, smoking status, total physical activity, history of hypertension, history of diabetes, history of dyslipidaemia, coffee consumption, green tea consumption, and occupation.